Lipitor: Brand Drug Name
Atorvaststin: Generic Drug Name
Cholesterol: Primary Disease Name
Lipitor Drug Interactions
Individuals who have active liver disease or unexplained persistent elevations
of serum transaminases should not take the medication. Concerning women of
child bearing age, since the active ingredient in Lipitor, HMG-CoA reductase
inhibitors, decrease cholesterol synthesis and possibly the synthesis of other
biologically active substances derived from cholesterol, they may cause fetal
harm when administered to pregnant women.Therefore, HMG-CoA reductase
inhibitors are contraindicated during pregnancy and in nursing mothers.
Atorvaststin SHOULD BE ADMINISTERED TO WOMEN OF CHILDBEARING AGE ONLY WHEN SUCH
PATIENTS ARE HIGHLY UNLIKELY TO CONCEIVE AND HAVE BEEN INFORMED OF THE
POTENTIAL HAZARDS. If the patient becomes pregnant while taking this drug,
therapy should be discontinued and the patient apprised of the potential hazard
to the fetus. In addition, individuals that have any know hypersensitivity to
any component of the medication should also refrain from taking Lipitor.
Are there any medications that significantly react with Lipitor?
The risk of myopathy during treatment with Lipitor is increased with concurrent
administration of cyclosporine, fibric acid derivatives, niacin (nicotinic
acid), erythromycin, azole antifungals.
Antacid: When atorvastatin and Maalox® TC suspension were
coadministered, plasma concentrations of atorvastatin decreased approximately
35%. However, LDL-C reduction was not altered.
Antipyrine: Because Lipitor does not affect the
pharmacokinetics of antipyrine, interactions with other drugs metabolized via
the same cytochrome isozymes are not expected.
Colestipol: Plasma concentrations of Lipitor decreased
approximately 25% when colestipol and atorvastatin were coadministered.
However, LDL-C reduction was greater when Lipitor and colestipol were
coadministered than when either drug was given alone.
Cimetidine: Lipitor plasma concentrations and LDL-C reduction
were not altered by coadministration of cimetidine.
Digoxin: When multiple doses of Lipitor and digoxin were
coadministered, steady-state plasma digoxin concentrations increased by
approximately 20%. Patients taking digoxin should be monitored appropriately.
Erythromycin: In healthy individuals, plasma concentrations of
Lipitor increased approximately 40% with coadministration of Lipitor and
erythromycin, a known inhibitor of cytochrome P450 3A4.
Oral Contraceptives: Coadministration of Lipitor and an oral
contraceptive increased AUC values for norethindrone and ethinyl estradiol by
approximately 30% and 20%. These increases should be considered when selecting
an oral contraceptive for a woman taking atorvastatin.
Warfarin: Atorvastatin had no clinically significant effect on
prothrombin time when administered to patients receiving chronic warfarin
treatment.
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